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Department of Animal Sciences
The Robert H. Smith Faculty
of Agricultural, Food & Environment

The Hebrew University of Jerusalem.

P.O. Box 12, Rehovot 76100, Israel
Phone: +972-(0)8-9489119;
Fax: +972-(0)8-9465763;
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Argov-Argaman, N. ; Hadaya, O. ; Glasser, T. ; Muklada, H. ; Dvash, L. ; Mesilati-Stahy, R. ; Landau, S. Y. Milk fat globule size, phospholipid contents and composition of milk from purebred and Alpine-crossbred Mid-Eastern goats under confinement or grazing condition. IDF International Symposium on Sheep, Goat and other non-Cow Milk 2016, 58, 2 - 8. Publisher's VersionAbstract
Milk fat globule (MFG) size and phospholipids (PL) content and composition were determined in milk collected at 65 (pretreatment), 110, 135 and 170 days of lactation from goats randomly assigned to grazing in Mediterranean brushland or fed clover hay indoors, in addition to concentrate. Daily feed intake and dietary contents of neutral detergent fibre and acid detergent fibre were higher in grazing goats, associated with milk richer in fat, with larger MFGs and 20% higher PL content. Smaller MFGs, produced by all confinement groups, was associated with 15 μg g−1 fat higher milk PL content. The greatest effect was found in the Damascus goats, with over 44% higher PL concentration, on milk fat basis, in the confined compared with grazing group. Our understanding of how PL content is modulated by the interaction between genetic background and nutrition will enable to achieve either PL-rich milk or PL-enriched milk fat.
Lubetzky, R. ; Argov-Argaman, N. ; Mimouni, F. B. ; Armoni Domany, K. ; Shiff, Y. ; Berkovitz, Z. ; Reifen, R. ; Mandel, D. Fatty acids composition of human milk fed to small for gestational age infants. The Journal of Maternal-Fetal & Neonatal MedicineThe Journal of Maternal-Fetal & Neonatal Medicine 2016, 29, 3041 - 3044. Publisher's Version
Ifrah, M. E. ; Perelman, B. ; Finger, A. ; Uni, Z. The role of the bursa of Fabricius in the immune response to vaccinal antigens and the development of immune tolerance in chicks (Gallus domesticus) vaccinated at a very young age. Poultry Scienceps 2016, 96, 51 - 57. Publisher's VersionAbstract
Vaccination is recognized to be the most cost-effective means of preventing, controlling, and even eradicating infectious diseases. Conventional poultry are vaccinated through various routes including eye/nose drops, drinking water, vent brush, or injection. Efficient vaccination is an essential part of any good poultry management.The bursa of Fabricius is intimately connected to the cloaca and the intestinal system. It is well-known as a primary lymphoid organ in the chicken and a major channel through which environmental antigens stimulate the immune system. In this study we tested whether direct instillation of various viral vaccines and antigens into the cloaca (per bursam), could stimulate higher antibody titers and generate improved protection. Despite the very rapid absorption of the vaccines or antigens from the cloaca to the lumen of the Bursa of Fabricius, per bursam inoculation failed to generate a satisfactory immune response. In contrast conventional administration of live or inactivated commercial vaccines led to an acceptable level of seroconversion and protection against challenge.An interesting finding in this study was the fact that administration of a single priming dose of antigenic material at age 1 or 5 days, did not improve the response to a second administration at 14 days of age as expected. Instead, in most cases there was a reduced serum antibody response suggesting the induction of tolerance. This was true for all routes of administration (intramuscular, per ocular and per bursam) and for all formulations of vaccine.The current study reveals: 1) no advantage for direct application of live or inactivated vaccines or antigens into the bursa of Fabricius compared to common routes of vaccination, 2) that apparent desensitization or tolerance effects have important implications for poultry management, since in many countries, vaccination of day old chicks is compulsory or a well-accepted part of flock vaccination.According to our results, early vaccination can in fact reduce or inhibit a secondary immune response to subsequent vaccination and increase susceptibility to disease agents.