In the Schlesinger lab, we study epigenetic reprogramming following fertilization. In particular, we are interested in the process leading to the formation of heterochromatin de novo and silencing of transposable elements and retroviruses. We use embryonic stem (ES) cells from mice and from farm animals to get a deeper understanding of the general characteristics of pluripotency in all mammalian cells.

Research interests:

The histone variant H3.3 and retroviral silencing	Mouse Embryonic Stem Cells (ESC) and retroviral silencing by the Smarcad1 chromatin remodeler	Bovine induced pluripotent stem cells	Bovine Mesenchymal Stem Cells response to heat	Transposable elements regulation in response to viral infection