Prof. Rina Meidan

Research Interests:

The corpus luteum (CL) plays a vital role in regulating the reproductive cycle, fertility, and in maintaining pregnancy. It is a transient endocrine gland that undergoes dynamic changes throughout its lifespan. Its formation, induced by LH, involves a complex process of cell differentiation and neovascularization. The new CL develops from the follicular cells remaining after oocyte expulsion; however, it is eventually composed of multiple, distinctive cell types including luteal steroidogenic cells (small and large cells that originate from theca and granulosa, respectively) and non-steroidogenic cells (luteal endothelial cells, pericytes, fibrocytes, and various immune cells. The CL produces progesterone to prepare the female reproductive tract to maintain a conceptus; however, in the absence of luteotrophic or antiluteolytic support, which occurs during maternal recognition of pregnancy by interferon-tau, the CL will regress due to prostaglandin F2a of uterine origin. Systemic concentrations of progesterone, during the cycle preceding and following insemination, affect the embryo survival rate. Therefore, abnormal CL function, also termed luteal insufficiency, has been implicated as a cause of pregnancy failures in farm animals. In addition, in women, a luteal phase defect is one of the reasons for implantation failure, which has been responsible for many cases of miscarriages and unsuccessful assisted reproduction.

The specific topics currently studied in my lab are:

  • Mechanisms controlling the demise or maintenance of the corpus luteum
  • Role of hypoxia in luteal formtion
  • Luteal functions of interferon Tau
  • Role of Sirtuin-1 in hypoxic regulation of luteal granulosa cells


Curriculum Vitae


  • Ph.D. - The Weizmann Instiute of Science, Rehovot Israel -1983
  • M.Sc. - The Weizmann Instiute of Science, Rehovot Israel -1978
  • B.Sc. - Bar Ilan University, Kiryat Ono, Israel -1975

Teaching Responsibilities:

71810 – Introductory Endocrinology
73503 - Biology of the Mammalian Ovary


List of Publications


Selected recent publications

  1. Farberov S, Basavaraja R, Meidan R. Thrombospondin-1 at the crossroads o corpus luteum fate decisions. Reproduction. 2018 Dec 1. pii: REP-18-0530.R2. doi:10.1530/REP-18-0530. [Epub ahead of print] Review. PubMed PMID: 30566900.
  2. Shrestha K, Meidan R. The cAMP-EPAC Pathway Mediates PGE2-Induced FGF2 in Bovine Granulosa Cells. Endocrinology. 2018 Oct 1;159(10):3482-3491. doi:10.1210/en.2018-00527. PubMed PMID: 30085093.
  3. Kfir S, Basavaraja R, Wigoda N, Ben-Dor S, Orr I, Meidan R. Genomic profiling  of bovine corpus luteum maturation. PLoS One. 2018 Mar 28;13(3):e0194456. doi:10.1371/journal.pone.0194456. eCollection 2018. PubMed PMID: 29590145; PubMed
    Central PMCID: PMC5874041.
  4. Farberov S, Meidan R. Fibroblast growth factor-2 and transforming growth factor-beta1 oppositely regulate miR-221 that targets thrombospondin-1 in bovine luteal endothelial cells. Biol Reprod. 2018 Mar 1;98(3):366-375. doi:10.1093/biolre/iox167. PubMed PMID: 29228113.
  5. Shrestha K, Onasanya AE, Eisenberg I, Wigoda N, Yagel S, Yalu R, Meidan R, Imbar T. miR-210 and GPD1L regulate EDN2 in primary and immortalized human granulosa-lutein cells. Reproduction. 2018 Feb;155(2):197-205. doi:10.1530/REP-17-0574. Epub 2018 Jan 4. PubMed PMID: 29301980.
  6. Basavaraja R, Przygrodzka E, Pawlinski B, Gajewski Z, Kaczmarek MM, Meidan R. Interferon-Tau Promotes Cell Survival and Inhibits Specific Luteolytic Genes in Bovine Corpus Luteum. Reproduction. 2017 Aug 14
  7. Farberov S, Meidan R. Thrombospondin-1 Affects Bovine Luteal Function via Transforming Growth Factor-Beta1-Dependent and Independent Actions. Biol Reprod. 2016 Jan;94(1):25.
  8. Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor.Khamaisi M, Toukan H, Axelrod JH, Rosenberger C, Skarzinski G, Shina A, Meidan R, Koesters R, Rosen S, Walkinshaw G, Mimura I, Nangaku M, Heyman SN.Kidney Int. 2015 Apr;87(4):761-70.
  9. Yalu R, Oyesiji AE, Eisenberg I, Imbar T, Meidan R. HIF1A-dependent increase in endothelin 2 levels in granulosa cells: role of hypoxia, LH/cAMP, and reactive oxygen species. Reproduction. 2015 Jan;149(1):11-20. Regulation of ovulatory genes in bovine granulosa cells: lessons from siRNA silencing of PTGS2.
  10. Shrestha K, Lukasik K, Baufeld A, Vanselow J, Moallem U, Meidan R. Regulation of ovulatory genes in bovine granulosa cells: lessons from siRNA silencing of PTGS2. Reproduction. 2015 Jan;149(1):21-9.
  11. Farberov S, Meidan R. Functions and transcriptional regulation of thrombospondins and their interrelationship with fibroblast growth factor-2 in bovine luteal cells. Biol Reprod. 2014 Sep;91(3):58.
  12. Skarzynski DJ, Piotrowska-Tomala KK, Lukasik K, Galvão A, Farberov S, Zalman Y, Meidan R.Growth and regression in bovine corpora lutea: regulation by local survival and death pathways. Reprod Domest Anim. 2013 Sep;48 Suppl 1:25-37. d
  13. Smith GW, Meidan R. Ever-changing cell interactions during the life span of the corpus luteum: relevance to luteal regression. Reprod Biol. 2014 Apr;14(2):75-82.
  14. Meidan R. Klipper E, Zalman Y, Yalu R. The role of hypoxia-induced genes in ovarian angiogenesis. Reprod Fertil Dev. 2013;25(2):343-50.
  15. Imbar T, Klipper E, Greenfield C, Hurwitz A, Haimov-Kochman R, Meidan R. Altered endothelin expression in granulosa-lutein cells of women with polycystic ovary syndrome. Life Sci. 2012 Oct 15;91(13-14):703-9.
  16. Ko C, Meidan R. Bridges PJ. Why two endothelins and two receptors for ovulation and luteal regulation? Life Sci. 2012 Oct 15;91(13-14):501-6.
  17. Shirasuna K, Akabane Y, Beindorff N, Nagai K, Sasaki M, Shimizu T, Bollwein H, Meidan R.Miyamoto A. Expression of prostaglandin F2α (PGF2α) receptor and its isoforms in the bovine corpus luteum during the estrous cycle and PGF2α-induced luteolysis. Domest Anim Endocrinol. 2012 Oct;43(3):227-38.
  18. Levit A, Yarnitzky T, Wiener A, Meidan R, Niv MY. Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs. PLoS One. 2011;6(11):e27990.
  19. Y Zalman , E Klipper, S Farberov , M Mondal, G Wee, JK. Folger, G W. Smith , and R Meidan. Regulation Of Angiogenesis-Related Prostaglandin F2a -Induced Genes In The Bovine Corpus Luteum 2011 Biol Reprod in press
  20. Mondal M, Schilling B, Folger J, Steibel JP, Buchnick H, Zalman Y, Ireland JJ, Meidan R, Smith GW. Deciphering the luteal transcriptome: potential mechanisms mediating stage-specific luteolytic response of the corpus luteum to prostaglandin F₂α. Physiol Genomics. 2011 Apr 27;43(8):447-56.
  21. Klipper E, Levit A, Mastich Y, Berisha B, Schams D, Meidan R. Induction of endothelin-2 expression by luteinizing hormone and hypoxia: possible role in bovine corpus luteum formation. Endocrinology. 2010 Apr;151(4):1914-22.
  22. Rayhman O, Klipper E, Muller L, Davidson B, Reich R, Meidan R. Small interfering RNA molecules targeting endothelin-converting enzyme-1 inhibit endothelin-1 synthesis and the invasive phenotype of ovarian carcinoma cells. Cancer Res. 2008 Nov 15;68(22):9265-73.
  23. Zhou QY, Meidan R. Biological function of prokineticins. Results Probl Cell Differ. 2008;46:181-99. Review.
  24. Meidan R, Levy N. The ovarian endothelin network: an evolving story. Trends Endocrinol Metab. 2007 Dec;18(10):379-85. Epub 2007 Nov 9. Review.
  25. Kisliouk T, Friedman A, Klipper E, Zhou QY, Schams D, Alfaidy N, Meidan R. Expression pattern of prokineticin 1 and its receptors in bovine ovaries during the estrous cycle: involvement in corpus luteum regression and follicular atresia. Biol Reprod. 2007 May;76(5):749-58. Epub 2007 Jan 17.
  26. Podlovni H, Ovadia O, Kisliouk T, Klipper E, Zhou QY, Friedman A, Alfaidy N, Meidan R.Differential expression of prokineticin receptors by endothelial cells derived from different vascular beds: a physiological basis for distinct endothelial function. Cell Physiol Biochem. 2006;18(6):315-26.
  27. Rosiansky-Sultan M, Klipper E, Spanel-Borowski K, Meidan R. Inverse relationship between nitric oxide synthases and endothelin-1 synthesis in bovine corpus luteum: interactions at the level of luteal endothelial cell. Endocrinology. 2006 Nov;147(11):5228-35.
  28. Klipper E, Levy N, Gilboa T, Muller L, Meidan R. Identification of a novel alternatively spliced variant endothelin converting enzyme-1 lacking a transmembrane domain. Exp Biol Med (Maywood). 2006 Jun;231(6):723-8.
  29. Kisliouk T, Podlovni H, Meidan R. Unique expression and regulatory mechanisms of EG-VEGF/prokineticin-1 and its receptors in the corpus luteum. Ann Anat. 2005 Nov;187(5-6):529-37. Review.
  30. Meidan R, Klipper E, Gilboa T, Muller L, Levy N. Endothelin-converting enzyme-1, abundance of isoforms a-d and identification of a novel alternatively spliced variant lacking a transmembrane domain. J Biol Chem. 2005 Dec 9;280(49):40867-74.


Lab Photos