Degrees:

• Ph.D. Biochemistry, The Hebrew University of Jerusalem, 1986
• M.Sc. Biochemistry, The Hebrew University of Jerusalem, 1981
• B.Sc. Animal Sciences, The Hebrew University of Jerusalem, 1979

Teaching Responsibilities:

Undergraduate:

71211 – Chromatography of Micro and Macromolecules
71805-  Introduction to Physiology A

Graduate:

73521 - Chromatography Systems in Biology
73522 - Laboratory in Chromatography Systems in Biology

 

2000

• Leshem, Y., Spicer, D.B., Gal-Levi, R., Halevy, O. (2000) Hepatocyte growth factor (HGF) inhibits skeletal muscle cell differentiation: a role for the bHLH protein twist and the cdk inhibitor p27. J. Cell. Physiol. 184:101-109.
• Halevy, O. , Geyra, A., Barak, M. , Uni, Z., and Sklan, D. (2000) Early posthatch starvation decreases satellite cell proliferation and skeletal muscle growth in chicks. J. Nutr. 130:858-864.
• Oron, U., Halevy, O., Yaakobi, T., Hayam, G., Gepstein, L., Wolf, T., Ben-Haim, S. (2000) Technical delivery of myogenic cells through an endocardial injection catheter for myocardial cell implantation. Int. J. Cardiovasc. Interv. 3: 227-330.

2001

• Shefer, G., Oron, U. , Irintchev, A., Wernig, A., Halevy, O. (2001) Skeletal muscle cell activation by low energy laser irradiation: a role for MAPK/ERK pathway. J. Cell. Physiol. 187: 73-80.
• Halevy, O., Krispin A., Leshem, Y., McMurtry, J.P., Yahav, S. (2001) Early-age-heat exposure affects skeletal muscle satellite cell proliferation and differentiation in chicks. Am. J. Physiol. Reg. Integr. Comp. C281:R302-R317.
• Shefer, G., Halevy, O., Cullen, M., Oron, U. (2001) Low energy laser irradiation shows no histopathological effect on myogenic satellite cells in tissue culture. Laser Therapy 11:114-117.

2002

• Leshem, Y., Halevy, O. (2002) Phosphorylation of pRb is required for HGF-induced muscle cell proliferation and is p27kip1-dependent. J. Cell. Physiol. 191:173-182.
• Leshem, Y., Gitelman, I., Ponzetto, C., Halevy, O. (2002) Preferential binding of Grb2 or phosphatidylinositol 3-kinase to the Met receptor has opposite effects on HGF-induced myoblast proliferation. Exp. Cell Res. 274:288-298.
• Shefer, G., Partridge, T., Heslop, L., Gross, J. G., Oron, U., Halevy, O. (2002) Low-energy laser irradiation promotes the survival and cell-cycle entry of skeletal muscle satellite cells. J. Cell Sci. 115:1461-1469.

2003

• Halevy, O., Nadel, Y., Barak, M., Rozenboim, I., Sklan, D. (2003) Early posthatch feeding stimulates satellite cell proliferation and skeletal muscle growth in turkey poults J. Nutr.133:1376-
• Sklan, D., Hiefez, S., Halevy, O. (2003). Heavier chicks at hatch improve marketing body weight by enhancing skeletal muscle growth. Poult. Sci. 72: 1778-1786.
• Rozenboim, R., Huisinga, R., Halevy, O. and El Halawani, M.E. (2003) Effect of embryonic photostimulation on post-hatch growth of turkey poults. Poult. Sci. 82: 1181-1187

2004

• Halevy, O. and Cantley, L.C. (2004) Differential regulation of the phosphoinositide 3-kinase and MAP kinase pathways by hepatocyte growth factor versus insulin-like growth factor-I in myogenic cells. Exp. Cell Res. 297: 224-233.
• Rozenboim I., Piestun, Y., Mubarki, N., Hoizman, A., Barak, M., Halevy O. (2004) Monochromatic light stimuli during embryogenesis enhances embryo development and posthatch growth. Poult. Sci. 83:1413-1419.
• Halevy, O., Piestun, Y., Allouh, M.Z., Rosser, B.W.C., Rinkevich, Y., Reshef, R. Rozenboim, I., Wleklinski, M., Yablonka-Reuveni, Z. (2004) The pattern of Pax7 expression during myogenesis in the posthatch chicken establishes a model for satellite cell differentiation and renewal. Dev. Dyn. 231:489-502.
• Rozenboim, I., Piestun, Y., Mubarki, N., Hoizman, A., Barak, M., Halevy O. (2004) Monochromatic light stimuli during embryogenesis enhances embryo development and posthatch growth. Poult. Sci. 83:1413-1419.

2006

• Halevy, O., Piestun, Y., Rozenboim, I., Yablonka-Reuveni, Z. (2006) In-ovo exposure to monochromatic green light promotes skeletal muscle cell proliferation and synchronizes myofiber development in posthatch chicks. Am. J. Physiol. 290: R1062-R1070.
• Halevy, O., Yahav, S., Rozenboim, I. (2006) Enhancement of meat production by environmental manipulation in embryo and young broilers. World's Poult. Sci. J. 62: 485-497.
• Gnainsky,Y., Spira, G., Paizi, M., Bruck, R., Nagler, A., Genina, O., Taub, R., Halevy, O., Pines, M. (2006) Involvement of the tyrosine phosphatase early gene of liver regeneration (PRL-1) in cell cycle and in liver regeneration and fibrosis- effect of halofuginone. Cell Tissue Res. 324: 384-395.

 

2007

• Elia, D., Madhala, D., Ardon, E., Reshef, R., Halevy, O. (2007) Sonic hedgehog promotes proliferation and differentiation of adult muscle cells: involvement of MAPK/ERK and PI3K/Akt pathways. Biochim. Biophys. Acta Mol. Cell Res. 1773:1438-1446.

2008

• Shefer, G., Ben-Dov, N., Halevy, O. , Oron U. (2008) Primary myogenic cells see the light: Improved survival of transplanted myogenic cells following low energy laser irradiation. Lasers Surg. Med. 40:38-45.
• Piestun, Y., Shinder, D., Brake, J., Halevy O., Yahav, S. (2008) Thermal manipulations during broiler embryogenesis: effect on the acquisition of thermotolerance. Poult. Sci. 78: 1-10.
• Turgeman, T., Huebner, K., Anderson, J., Genina, O., Nagler, A., Halevy, O., Pines, M. (2008). Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginone. Neuromuscul. Disord. 18: 857-868.
• Huebner, K.D., Jassal, D.S., Halevy, O., Pines, M., Anderson, J.E. (2008) Functional resolution of fibrosis in mdx mouse dystrophic heart and skeletal muscle by halofuginone. Am. J. Physiol. Heart Circ. Physiol. 294: H1550-1561.
• Piestun, Y., Shinder, D., Halevy O., Yahav, S. (2008) The effect of thermal manipulations during development of the thyroid and adrenal axes on in-hatch and post-hatch thermoregulation. J. Thermal. Biol. 33:413-418.

2009

• Piestun, Y., Harel, M., Barak, M., Yahav, S., Halevy. O. (2009) Thermal manipulations in late-term chick embryos have immediate and longer term affects on myoblast proliferation and skeletal muscle hypertrophy. J. Appl. Physiol. 106:233-240.
• Piestun, Y., Halevy O., Yahav, S. (2009) Thermal manipulations of broiler embryos: ­The effect on thermoregulation and development during embryogenesis. Poult. Sci. 88: 2677-2688.
• Kornasio, R., Rierder, I., Butler-Browne, G., Mouly, V., Uni, Z., Halevy, O. (2009) HMB promotes muscle cell proliferation and differentiation and inhibits apoptosis. Biochim. Biophys. Acta Mol. Cell Res. 1793:755-763.
• Zion, O. , Genin, O. , Kawada, N., Yoshizato, K., Roffe, S., Nagler, A., Iovanna, J.L., Halevy, O. , Pines, M. (2009) Inhibition of TGF• signaling by halofuginone as a modality for pancreas fibrosis prevention. Pancreas. 37: 527-435

2010

• Roffe, S., Hagai, Y., Pines M., Halevy O. (2010) Halofuginone inhibits Smad3 phosphorylation via the PI3K/Akt and MAPK/ERK pathways in muscle cells: effect on myotube fusion. Exp. Cell Res. 316:1061-1069.
• Nevo, Y. Halevy, O. Genin, O. Moshe, I., Turgeman, T., Harel, M., Biton, E., Rief, S., Pines, M. (2010) Fibrosis inhibition and muscle characteristics improvement in laminin-•2 deficient mice. Muscle Nerve 42: 218-229.

2011

• Halevy, O., Pines, M. (2011) Halofuginone and muscular dystrophy. Review. Histol. Histopathol. 26:135-146.
• Kornasio, R., Kedar, O., Halevy O., Uni, Z. (2011) The effect of in-ovo feeding and its interaction with first-feed timing on glycogen reserves, muscle growth and body weight. Poult. Sci. 90:1467-1477.
• Piestun Y., Halevy O., Shinder D., Ruzal M., Druyan S., Yahav S. (2011) Thermal manipulations during broiler embryogenesis improves post hatch performance under hot condition. J. Thermal Biol. 36:469-474.

2012

• Madhala-Levy, D., Reshef, R., Williams, V., Hughes, S., Halevy, O. (2012) Mutual relationships between Shh and IGF-I via the MAPK/ERK and PI3K/Akt pathways in skeletal muscle myoblasts. J. Cell. Physiol. 227: 1455–1464.

2013

• Rozenboim, I., El Halawani, M.E., Kashash, Y., Piestun, Y., Halevy, O. (2013) The effect of monochromatic photostimulation on growth and development of broiler birds. Gen. Comp. Endocrinol. Review. 190: 214-219.
• Halevy, O., Genin, O., Barzilai-Tutcsh, H., Pima, Y., Levi., O., Moshe, I., and Pines, M. (2013) Inhibition of muscle fibrosis and improvement of muscle histopathology in dysferlin knock-out mice treated with halofuginone. Histol. Histolpathol. 28: 211-226.
• Spector, I., Lavi, A., Genin, O., Barzilai-Tutsch, H., Bodanovsky, A., Halevy, O., and Pines, M. (2013) The involvement of Collagen triple helix repeat containing 1 in muscular dystrophies- effect of halofuginone. Am. J. Pathol. 182:905-916.

2014

• Hadad, Y., Halevy O., Cahaner, A. (2014) Featherless and feathered broilers under control versus hot conditions. 1. Breast meat yield and quality. Poult. Sci. 93:1067–1075.
• Hadad, Y., Cahaner, A., Halevy, O. (2014) Featherless and feathered broilers under control versus hot conditions. 2. Breast muscle development and growth in pre- and post-hatch periods. Poult. Sci. 93:1076–1087.
• Bodanovsky A., Guttman, N., Barzilai-Tutcsh, H., Levy, O., Pines, M., Halevy, O. (2014) Halofuginone improves cell survival in muscular dystrophies. Biochem. Biophys. Acta Mol. Cell Res. 1843: 1339-1347.

2015

• Levy O., Genin O., Angelini C., Fanin M., Halevy O., Pines M. (2015) Inhibition of muscle fibrosis results in increases in both utrophin levels and the number of revertant myofibers in Duchenne muscular dystrophy. Oncotarget 6:23249-23260.
• Harding, R.L., Clark, D.L., Halevy, O., Coy, C.S., Yahav, S., Velleman, S.G. (2015). The effect of temperature on apoptosis and adipogenesis on skeletal muscle satellite cells derived from different muscle types. Physiol. Rep. 3. e12539 doi: 10.14814/phy2.12539.
• Piestun, Y., Yahav, S., Halevy, O. (2015) Thermal manipulation during embryogenesis affects myoblast proliferation and skeletal muscle growth in meat-type chickens. Poult. Sci. 94:2528-2536.

2016

• Barzilai-Tutcsh, H., Bodanovsky A., Maimon, H., Pines, M., Halevy, O. (2016) Halofuginone promotes satellite cell activation and survival in muscular dystrophies. Biochem. Biophys. Acta – Mol. Basis Dis. 1862:1-11.
• Harding, R.L., Halevy, O., Yahav, S., Velleman, S.G (2016) The effect of temperature on proliferation and differentiation of skeletal muscle satellite cells isolated from different muscle types. Physiol. Rep. 4, e12539, doi: 10.14814/phy2.12539.

2017

• Pines, M., Levi, O., Genin, O., Lavi, A., Angelini, C., Allamand, V., and Halevy, O. (2017) Elevated expression of moesin in muscular dystrophies. Am. J. Pathol. 187: 654-667.
• Piestun, Y., Patael, T., Yahav, S., Velleman, S.D., Harding, R.L. Coy, C.S., and Halevy, O. (2017) Early post-hatch thermal stress affects broiler muscle development and satellite cell fate. Poult. Sci. 96: 2877-2888.

2018

• Barzilai-Tutsch, H., Dewulf, M., Lamaze, C., Butler Browne, G., Pines, M., and Halevy, O. (2018) ­A promotive effect for halofuginone on membrane repair and synaptotagmin-7 levels in muscle cells of dysferlin-null mice. Hum. Mol. Gent. 16: 2817–2829.

2019

• Wellner, G.*, Mordecai, S*., Evans, P., Genin, O., Pines, M., and Halevy O. (2019) Hydroxy group requirement for halofuginone-dependent inhibition of muscle fibrosis and improvement of histopathology in the mdx mouse model for Duchenne muscular dystrophy. Histol. Histopathol. J. 34:791-801.
• Patael, T.*, Piestun, Y.*, Soffer, A., Mordechai, S., Yahav, S., Velleman, S.G., and Halevy, O. (2019) Early posthatch thermal stress causes long-term adverse effects on pectoralis muscle development in broilers. Poult. Sci. 98:3268-3277.

2020

• Halevy, O. (2020) Timing is everything - the high sensitivity of avian satellite cells to thermal conditions during embryonic and posthatch periods. Front. Physiol. 11:235. doi: 10.3389/fphys.2020.00235. Review.
• Barzilai-Tutsch, H., Genin, O., Pines, P., and Halevy, O. (2020) Early pathological signs in young dysf-/- mice are improved by halofuginone. Neuromuscul. Disord. 30:472-482. doi: 10.1016/j.nmd.2020.04.001.

2021

• Mordechay, S., Evans, P., Genin, O., Pines, P., and Halevy, O. (2021) Differential effects of halofuginone enantiomers on muscle fibrosis and histopathology in Duchenne muscular dystrophy.  Int. J. Mol. Sci.  22:7063-7073.  https://doi.org/10.3390/ijms22137063.

2022

• Halevy, O. and Velleman, S.G. (2022) Skeletal Muscle. Sturkie's Avian Physiology (Seventh Ed.). p 565-589. Book Chapter.

2023

• Dayan, J., Melkman-Zehavi, T., Reicher, N., Braun, U., Inhuber, V., Mabjeesh, S.J., Halevy, O., and Uni, Z. (2023) Supply and demand of creatine andglycogen in broiler chicken embryos. Front. Physiol. 14:1079638. doi: 10.3389/fphys.2023.1079638
• Dayan, J., Goldman, N., Weiger, D., Melkman-Zehavi, T., Halevy, O., and Uni, Z. (2023) A deep learning-based automated image analysis for histological evaluation of broiler pectoral muscle. Poult. Sci. 102:102792. doi:10.1016/j.psj.2023.102792
• Dayan, J., Melkman-Zehavi, T., Goldman, N., Soglia, F., Zampiga, M., Petracci, M., Sirri, F., Braun, U., Inhuber, V., Halevy, O., and Uni, Z. (2023) In-ovo feeding with creatine monohydrate: implications for chicken energy reserves and breast muscle development during the pre-post hatching period". Front. Physiol.  14:1296342. doi: 10.3389/fphys.2023.1296342. E-collection.